Author's response to reviews Title: Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study Authors:

Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study

BACKGROUND Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume. METHODS Voxel based morphometry (VBM), corrected for total intracranial volume, age, BMI, years of education...

Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study

The recent literature on anorexia nervosa (AN) suggests that functional and structural abnormalities of cortico-limbic areas might play a role in the evolution of the disease. We explored global and regional brain volumes in a cross-sectional and follow-up study on adolescents affected by AN. Eleven adolescents with AN underwent a voxel-based morphometry study at time of diagnosis and immediate...

Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies

BACKGROUND Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done. METHODS In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using glob...

Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study

BACKGROUND Anorexia nervosa (AN) has consistently been associated with reduced gray (GM) and white matter (WM) brain volumes. It is unclear whether GM alterations are present following recovery from AN, as previous findings are inconsistent. The aim of the present study was to determine if women recovered from AN exhibit reduced global or regional GM volumes. METHODS Global GM and WM, as well...

Author's response to reviews Title: Emotional facial expression in women recovered from anorexia nervosa Authors: